영아기 자폐증 5세넘으면 사라질수도 있습니다.

 JAMANETWORK.COM (미국의사협회저널) 에 2023 년 10월 2일 발표된  
'Persistence of Autism Spectrum Disorder From Early Childhood Through School Age '
(유아기부터 학령기까지의 자폐스펙트럼 장애의 지속성)
 
관련해서 좋은 소식을 우리 발달장애 아이를 키우는 부모님께 알려드리고자 합니다.
 
아래 영어원문과 출처 웹사이트를 기재했으니 확인해보시기 바라며, 간단한 설명만 드리겠습니다.
 
이연구는 다음과 같은 궁금점으로 인하여 시작했습니다.
 
생후 12개월에서 36개월에 자폐 스펙트럼 장애(ASD)로 임상적 진단을 받은 아이들이 5세에서 7세에 기능을 바탕으로 ASD의 기준을 계속 충족하는 빈도는 얼마인가 ?
 
미국 보스턴 대학 아동병원 엘리자베스 하스타드 교수 연수팀은 생후 12개월에서 36개월사이에 자폐증 장애 진단을 받은 아이들 213명 (평균연령 24.6개월, 남아 177명, 여아 36명)을 5세에서 7세가 될 때까지 추적 관찰한 결과 , 이들중 79명(37.1%)은 5세에서 7세 (평균연령 74.3개월)사이에 자폐증 진단 기준에서 벗어난것으로 나타났다고 연구팀은 밝혔습니다.
 
여기서 중요한 점은 이 연구결과에 포함된 아이들은 모두 ASD 관련 치료를 받았습니다.
 
 
 
원문입니다.
 
 
https://jamanetwork.com/journals/jamapediatrics/article-abstract/2810092?resultClick=1

Persistence of Autism Spectrum Disorder From Early Childhood Through School Age

 
 

Original Investigation

October 2, 2023

Persistence of Autism Spectrum Disorder From Early Childhood Through School Age

Elizabeth Harstad, MD, MPH1; Ellen Hanson, PhD1; Stephanie J. Brewster, MS, CGC1,2; et alRafael DePillis, BS1; Anna L. Milliken, BA1; Gabriella Aberbach, MSc1; Georgios Sideridis, PhD1; William J. Barbaresi, MD1

Author Affiliations

JAMA Pediatr. Published online October 2, 2023. doi:10.1001/jamapediatrics.2023.4003

 

FullText

Key Points

Question  What is the frequency with which children diagnosed clinically with autism spectrum disorder (ASD) at 12 to 36 months of age continue to meet criteria for ASD based on functioning at 5 to 7 years of age, and what factors are associated with ASD persistence?

Findings  Of the 213 children in this cohort study, 79 (37%) had nonpersistent ASD. Higher baseline adaptive functioning and female sex were associated with nonpersistent ASD.

Meaning  These findings suggest that an ASD diagnosis in a child younger than 3 years may not persist, and child-specific factors may be associated with persistence.

Abstract

Importance  While the prevalence of autism spectrum disorder (ASD) continues to increase and early diagnosis is emphasized, there is limited information on outcomes for children diagnosed with ASD in early childhood using contemporary diagnostic criteria.

Objectives  To determine the frequency with which children who are clinically diagnosed with ASD at 12 to 36 months of age continue to meet diagnostic criteria for ASD at 5 to 7 years of age and to evaluate whether baseline child-specific and demographic characteristics and receipt of interventions are associated with ASD persistence.

Design, Setting, and Participants  In this natural history cohort study, children who received a clinical ASD diagnosis at 12 to 36 months of age underwent a research diagnostic assessment at 5 to 7 years of age. Research assessments occurred from August 14, 2018, to January 8, 2022.

Intervention  Children received community-based interventions, and parents provided details about interventions received.

Main Outcomes and Measures  The main outcome was persistence of ASD diagnosis based on current functioning. An experienced research psychologist assigned an ASD diagnosis (present or absent) according to criteria from the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) after the research assessment. The research assessment included administration of the Autism Diagnostic Observation Schedule–2, Autism Diagnostic Interview–Research, and a cognitive measure.

Results  Of the 213 participants diagnosed with ASD at initial clinical assessment (mean [SD] age, 24.6 [3.9] months; 177 boys [83.1%]), 79 (37.1%) did not continue to meet diagnostic criteria for ASD (nonpersistent ASD) at research assessment (mean [SD] age, 74.3 [7.1] months). All children with nonpersistent ASD had IQ of at least 70, while there was a bimodal distribution of IQ for those with persistent ASD (46 with IQ <70 and 88 with IQ ≥70). All children received some interventions, and 201 (94.4%) received ASD-specific intervention, mostly applied behavioral analysis. In a multilevel logistic regression model, the only variables associated with increased odds of being in the nonpersistent ASD group at 6 years of age were higher baseline adaptive skills (b coefficient = −0.287 [SE, 0.108]) and female sex (b = 0.239 [SE, 0.064]).

Conclusions and Relevance  The findings of this cohort study suggest that among toddlers diagnosed with ASD, baseline adaptive function and sex may be associated with persistence of ASD.